Rotenone

MedEd Pesticide lists Rotenone as an insecticide in the botanical (rotenoid) class.

MedEd Pesticide Summarizes Rotenone at a Glance

Type

Insecticide

Chemical class

Botanical (rotenoid)

CAS number

83-79-4

Formula

C23H22O6

Molar mass

394.4 g/mol

EU status

Not approved as an active substance in the EU.

US status

Registered with EPA. 7 active products contain Rotenone.

MedEd Pesticide Summarizes Rotenone’s Toxicity Records

MedEd Pesticide holds 192 toxicity records for Rotenone, from 6 sources. The headline values are below.

Oral LD50 in ratsAcute, swallowed

Lowest reported 60 mg/kg, median 96 mg/kg, from 2 records.

Dermal LD50Acute, skin contact

Lowest reported 940 mg/kg, median 970 mg/kg, from 2 records.

Lowest NOAELLong term, mammals

0.375 mg/kg-day in rat, 2 years. Source: ToxRefDB.

EPA signal wordsActive US products

Danger 6, Warning 1, Caution 0.

See all 192 Rotenone toxicity records in the explorer. The records come from EPA’s Toxicity Values Database, and the methodology explains their limits.

MedEd Pesticide Reports Rotenone’s EU Safety Reference Values

MedEd Pesticide finds no safety reference values for Rotenone in the EU database.

MedEd Pesticide Lists Rotenone’s EU Hazard Classification

MedEd Pesticide finds no harmonised hazard classification for Rotenone in the EU database.

MedEd Pesticide takes EU status, reference values and hazard classification from the EU Pesticides Database. MedEd Pesticide takes US status from EPA’s Pesticide Product Information System (dated 2026-10-13) and chemical identity from PubChem. Retrieved 2026-10-16. Values and approvals change, so check the source for the current entry. See the methodology and the glossary, or compare Rotenone with another pesticide.

MedEd Pesticide. (2026). Rotenone. https://mededpesticide.org/pesticides/rotenone/ (accessed Month Day, Year)