Glyphosate

MedEd Pesticide lists Glyphosate as a herbicide in the phosphonoglycine class.

MedEd Pesticide Summarizes Glyphosate at a Glance

Type

Herbicide

Chemical class

Phosphonoglycine

CAS number

1071-83-6

Formula

C3H8NO5P

Molar mass

169.07 g/mol

EU status

Approved in the EU since 16/12/2023, current approval expires 15/12/2033.

US status

Registered with EPA. 517 active products contain Glyphosate.

MedEd Pesticide Summarizes Glyphosate’s Toxicity Records

MedEd Pesticide holds 110 toxicity records for Glyphosate, from 7 sources. The headline values are below.

Oral LD50 in ratsAcute, swallowed

Lowest reported 4230 mg/kg, median 4551.5 mg/kg, from 2 records.

Dermal LD50Acute, skin contact

Lowest reported 7940 mg/kg, median 7940 mg/kg, from 1 record.

Lowest NOAELLong term, mammals

10 mg/kg-day in rat. Source: ToxRefDB.

EPA signal wordsActive US products

Danger 62, Warning 51, Caution 404.

See all 110 Glyphosate toxicity records in the explorer. The records come from EPA’s Toxicity Values Database, and the methodology explains their limits.

MedEd Pesticide Reports Glyphosate’s EU Safety Reference Values

MedEd Pesticide takes these values from the EU, which sets them when it assesses an active substance. They are expressed per kilogram of body weight.

ADIAcceptable daily intake

0.5 mg/kg bw/dayThe amount a person can take in every day over a lifetime without appreciable health risk.

ARfDAcute reference dose

1.5 mg/kg bwThe amount that can be taken in over a short period, such as one meal or one day, without appreciable health risk.

AOELAcceptable operator exposure level

0.1 mg/kg bw/dayThe level of exposure for people who apply the pesticide at which no adverse effect is expected.

MedEd Pesticide Lists Glyphosate’s EU Hazard Classification

MedEd Pesticide lists the harmonised EU hazard statements for Glyphosate below.

• H411 Toxic to aquatic life with long-lasting effects
• H318 Causes serious eye damage

MedEd Pesticide takes EU status, reference values and hazard classification from the EU Pesticides Database. MedEd Pesticide takes US status from EPA’s Pesticide Product Information System (dated 2026-10-13) and chemical identity from PubChem. Retrieved 2026-10-16. Values and approvals change, so check the source for the current entry. See the methodology and the glossary, or compare Glyphosate with another pesticide.

MedEd Pesticide. (2026). Glyphosate. https://mededpesticide.org/pesticides/glyphosate/ (accessed Month Day, Year)