Clothianidin

MedEd Pesticide lists Clothianidin as an insecticide in the neonicotinoid class.

MedEd Pesticide Summarizes Clothianidin at a Glance

Type

Insecticide

Chemical class

Neonicotinoid

CAS number

210880-92-5

Formula

C6H8ClN5O2S

Molar mass

249.68 g/mol

EU status

Not approved as an active substance in the EU.

US status

Registered with EPA. 69 active products contain Clothianidin.

MedEd Pesticide Summarizes Clothianidin’s Toxicity Records

MedEd Pesticide holds 169 toxicity records for Clothianidin, from 7 sources. The headline values are below.

Oral LD50 in ratsAcute, swallowed

Lowest reported 389 mg/kg, median 389 mg/kg, from 1 record.

Dermal LD50Acute, skin contact

Lowest reported 2000 mg/kg, median 2000 mg/kg, from 1 record.

Lowest NOAELLong term, mammals

9.8 mg/kg-day in rat. Source: ToxRefDB.

EPA signal wordsActive US products

Danger 0, Warning 6, Caution 38.

See all 169 Clothianidin toxicity records in the explorer. The records come from EPA’s Toxicity Values Database, and the methodology explains their limits.

MedEd Pesticide Reports Clothianidin’s EU Safety Reference Values

MedEd Pesticide takes these values from the EU, which sets them when it assesses an active substance. They are expressed per kilogram of body weight.

ADIAcceptable daily intake

0.097 mg/kg bw/dayThe amount a person can take in every day over a lifetime without appreciable health risk.

ARfDAcute reference dose

0.1 mg/kg bwThe amount that can be taken in over a short period, such as one meal or one day, without appreciable health risk.

AOELAcceptable operator exposure level

0.1 mg/kg bw/dayThe level of exposure for people who apply the pesticide at which no adverse effect is expected.

MedEd Pesticide Lists Clothianidin’s EU Hazard Classification

MedEd Pesticide lists the harmonised EU hazard statements for Clothianidin below.

• H302 Harmful if swallowed
• H400 Very toxic to aquatic life
• H410 Very toxic to aquatic life with long-lasting effects

MedEd Pesticide takes EU status, reference values and hazard classification from the EU Pesticides Database. MedEd Pesticide takes US status from EPA’s Pesticide Product Information System (dated 2026-10-13) and chemical identity from PubChem. Retrieved 2026-10-16. Values and approvals change, so check the source for the current entry. See the methodology and the glossary, or compare Clothianidin with another pesticide.

MedEd Pesticide. (2026). Clothianidin. https://mededpesticide.org/pesticides/clothianidin/ (accessed Month Day, Year)